Team & responsibilities

Operational leadership, academic advising, and clinical collaboration

One study, two complementary forms of leadership

Alejandra Benavides Rojas leads the experimental and primary analytical pipeline. Dr. Sandra Perdomo advises the scientific strategy, protocol, interpretation, and computational extensions. Their work converges on the same specimens and sequencing files, allowing methylation, immune, and—subject to feasibility—fragmentomic signals to be interpreted together.

TipThe research group behind the project

The study is connected to InMubo, the Cellular and Molecular Immunology Research Group at Universidad El Bosque. The university describes a program spanning cancer immunology, mucosal immunity and infection, autoimmunity, systemic inflammation, and research training. Read Universidad El Bosque’s profile of InMubo →

OPERATIONAL LEAD

Angie Alejandra Benavides Rojas

M.Sc. investigator · Basic Biomedical Sciences

Ale leads the end-to-end generation and primary analysis of study evidence:

  • coordinate sample processing and plasma separation;
  • prepare tissue DNA and plasma cfDNA;
  • construct EM-seq libraries and coordinate sequencing;
  • quantify serum sIgA by ELISA;
  • run methylation preprocessing and quality control;
  • identify differential methylation with DSS; and
  • integrate laboratory measurements with clinical variables.

THESIS ADVISOR

Dr. Sandra Perdomo

Dr. Sandra Perdomo wearing a laboratory coat at Universidad El Bosque

Dr. Sandra Perdomo at Universidad El Bosque.

Photo: Universidad El Bosque.

Advisor · Universidad El Bosque

Sandra provides scientific and translational direction:

  • ground the hypothesis in colitis and cancer biology;
  • verify protocol, regulatory, and analytical coherence;
  • guide fragmentomics feasibility and interpretation;
  • direct comparison with public cancer resources;
  • connect DMRs to pathways and biological systems; and
  • keep exploratory findings aligned with validation requirements.

Clinical network

Recruitment and screening are described as taking place with gastroenterologists Viviana Parra, Cristian Flores, and Ricardo Villareal across Los Cobos Medical Center, GastroAdvanced, and HIC Bucaramanga.

The project presentation identifies approval by the HIC Bucaramanga–Fundación Cardiovascular de Bucaramanga research committee under Minutes 005-2024, with the study framed under Colombian Resolution 8430 of 1993.

How responsibilities connect

flowchart LR
  C["Clinical network<br/>screening + specimens"] --> A["Ale<br/>wet lab + core analysis"]
  S["Sandra<br/>strategy + oversight"] --> A
  A --> M["Methylation + sIgA<br/>primary evidence"]
  M --> X["Fragmentomics +<br/>external validation"]
  S --> X
  X --> I["Integrated biological<br/>interpretation"]
  I --> V["Replication and<br/>future translation"]

Credit and authorship

This page describes project functions, not publication-author order or ownership. Authorship, intellectual property, and reuse of project materials should follow the team’s written agreements and institutional policies as the work develops.

Back to top